Defense Against Toxic Weapons: Intelligence that Protects the Soldier
by David R. Franz
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Defense Against Toxic Weapons
The Future
INTELLIGENCE: Information that protects soldiers
Readers of this document should now understand several important points
about protecting soldiers and targets of terrorist attack from toxin weapons:
1) Fifteen to twenty of some 400 known toxins have the physical
characteristics that make them threats against U.S. forces as potential
MCBWs. However, many toxins could be used in weapons to produce militarily
significant/terrorist (psychological) effects-especially in poorly educated
troops or in uninformed civilian populations.
2) Effective individual physical protective gear is available; soldiers must
receive timely warning of an attack, however, if they are to use their
protective masks effectively.
3) Most of the toxins with the characteristics that make them threats as
MCBW are proteins, which is to our advantage; vaccines or passive antibody
therapy are developed relatively easily.
4) Immunizing troops, much preferred to treating intoxicated troops after
exposure, typically requires a minimum of 4-15 weeks.
5) Development of medical countermeasures against likely MCBWs is feasible.
In addition, research for and development of a vaccine or passive antibody
therapy through final approval by the U.S. Food and Drug Administration as a
product for human use is likely to require a minimum of 4-7 years (8-10
years in some cases). Because developing and producing countermeasures takes
years, intelligence information regarding toxin research for weapons
development and aggressor capability analysis is invaluable. Our own
understanding of the physical characteristics of toxins, even without
intelligence information, allows us to deduce what may be possible for the
aggressor; this information reduces the list of toxins from hundreds to less
than 20. Good intelligence on threat research and development can, at a
minimum, help those responsible for research and development of medical
countermeasures prioritize finite resources, and thus reduce the time of the
research and development cycle. Good intelligence on weaponized toxins held
by an aggressor will also greatly assist leaders who must makedecisions to immunize troops as they ppare for conflict. Therefore, as
regards medical defense against toxin weapons, a strong and effective
intelligence effort is both necessary and cost-effective.
TOXINS AS WEAPONS
Research literature suggests that we have discovered the majority of the
"most toxic" (LD50 < 0.0025 micrograms/kilogram) naturally occurring toxins.
New toxins of lesser toxicity, especially the venom toxins, are being
discovered at the rate of perhaps 10-30 per year. There is little precedence
in the literature for artificially increasing the toxicities of naturally
occurring toxins; however, it might be possible to increase the physical
stability of toxins that are toxic enough but too unstable to weaponize.
This could increase the effectiveness of the threat toxins.
It is unlikely that chemical synthesis of complex nonprotein toxins will
become significantly easier in the near future. It is likely, however, that
large-scale biosynthesis of peptide toxins of 10-15 amino acids (some of the
venom toxins) will become possible in the next few years.
I have attempted to present a rationale for focusing our medical biological
defense resources on the development of medical countermeasures for those
toxins that our soldiers are most likely to face on the battlefield in the
next 5 years. We must also continue limited basic research efforts and
maintain "technical watch" of the peptide and other toxins that could become
the next generation of toxin weapons. Medical defense against biological
weapons requires constant vigilance, especially today, because biotechnology
is now available worldwide.
COUNTERMEASURES TO TOXINS
Although the threat of toxin weapons of the future is formidable, the
prospect of new and better medical countermeasures is brighter than ever
before. Biotechnology may have more value to those of us developing
countermeasures than to those who would use toxins maliciously. Molecular
biological techniques developed in the last few years now allow us to
produce more effective and less expensive vaccines against the protein and
peptide toxins. Such vaccines will likely be available for the most
important toxins within the next few years. We are making good progress on
developing recombinant vaccines for certain highthreat toxins. Similar
technology allows us to produce human antibodies, which will eventually
replace those now produced in animals. Human antibodies will be a
significant advance over despeciated horse antibodies, allowing us to
protect unvaccinated soldiers by simply giving them an injection before they
go into battle, thereby providing immediate protection. Human antibodies
could also find application in counterterrorism as therapy.
PROTECTING SOLDIERS
Protecting soldiers on the battlefield from toxins-and replicating agents-is
possible if we use our combined resources effectively. Physical
countermeasures such as the protective mask, clothing and decontamination
capabilities exist and are effective; as we improve our battlefield detection
systems, early warning of our soldiers may become a reality, at least in
subpopulations within our forces. These assets, unlike most medical
countermeasures, are generally generic and protect against most or all of
the agents. Among the medical countermeasures, vaccines are available and
effective for some of the most important agents and therapies exist for
others. Because of limited resources available to develop vaccines,
diagnostics and therapies, we can field specific medical countermeasures
only to a relatively small group of threat agents. Our efforts in this area
must be carefully focused. A third and complementary element of our
defensive program must be good intelligence. Only through knowledge of
specific threat agents, delivery systems, and national capabilities can we
assure effective development and use of our physical and medical
countermeasures.
Finally, our renewed understanding of the real strengths and weaknesses of
toxins as weapons allows us to put them in perspective in educating our
soldiers, removing much of the mystique-and associated fear-surrounding
toxins. Knowledge of the threat thus reduces the threat to our soldiers.
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